Start date: 01/01/2023. Prospective registry: 29/03/2024-29/03/2029.
AIRC MFAG project
Location Matters
Improving the success rate for thoracic radiotherapy through specific cardiac substructure dosimetry and imaging-based cardiovascular risk stratification.
Scientific Aim
Location Matters addresses a central limitation in thoracic radiotherapy: the heart is not a single homogeneous organ, and the location of dose within cardiac substructures may influence toxicity and survival.
The project combines dosimetry, clinical information, quantitative imaging, and cardiovascular modelling to improve risk stratification for locally advanced lung cancer patients treated with radiotherapy, chemotherapy, and immunotherapy.
The long-term objective is to support treatment strategies that preserve oncological efficacy while reducing treatment-related cardiovascular risk.
Scientific Contributions
Conference abstracts, papers, protocol records, and outputs associated with the project.
Abstracts
ESTRO 2026 contribution on CT-derived cardiovascular risk factors in lung cancer patients treated with chemo-radio-immunotherapy and their relevance for 2-year post-radiotherapy survival.
Papers / outputs
ClinicalTrials.gov registration NCT06361784. ResearchGate preprint: CT-Derived Cardiovascular and Metabolic Biomarkers for Risk Stratification in Locally Advanced Lung Cancer Undergoing Combined-Modality Therapy. Manuscript status to be updated when peer-reviewed records are available.
Items marked as to be confirmed should be replaced when the final bibliographic record, DOI, or author list is available.
