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Translational cardio-oncology

BIONCARD

Identifying surrogate oncological outcome biomarkers through a translational study of anti-VEGF/TKI-induced cardiovascular effects in a pan-cancer cohort.

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Project durationStart date: 09/06/2025

End date to be confirmed.

Funding body5x1000 / healthcare research funds

Final administrative wording to be confirmed because public sources use both institutional 5x1000 and Ministry of Health wording.

Institutions involvedFondazione IRCCS Istituto Nazionale dei Tumori

Department of Advanced Diagnostic Services, Cardiology, Medical Oncology, Data Science / CMON Lab.

Researchers involvedPaola Vallerio, PI; Chiara Veronese, Co-PI; Alessandro Cicchetti, modelling analysis lead

Based on public INT profiles and project pages.

Scientific Aim

BIONCARD investigates cardiovascular and vascular effects induced by anti-VEGF and VEGFR/TKI therapies in a tumour-agnostic oncology cohort.

The project aims to identify more sensitive surrogate biomarkers of treatment activity and toxicity before overt cardiovascular complications appear.

The modelling component links non-invasive measurements, imaging features, systemic microvascular parameters, tumour response, and treatment management decisions.

Scientific Contributions

Conference abstracts, papers, protocol records, and outputs associated with the project.

Abstracts

To be updated when conference abstracts become public.

Papers / outputs

Protocol and modelling outputs to be updated after public release or publication.

Items marked as to be confirmed should be replaced when the final bibliographic record, DOI, or author list is available.

Reference Links